Hypoadiponectinemia in obese and diabetic subjects in the State of Qatar

Obesity is commonly associated with insulin resistance [IR], and is a common cause of type 2 diabetes. Adiponectin is an adipose tissue protein that enhances insulin sensitivity and has anti-atherogenic properties This study was done to determine the adiponectin level and its relations to key components of the metabolic syndrome in obese diabetic [OD], obese non-diabetic [OB] and control [non-obese, non-diabetic [NOND]] Qatari subjects We examined 64 [OD], 61 [OB] and 72 [NOND] male and female subjects. After a 12 h overnight fasting, blood samples were withdrawn for determination of plasma glucose, insulin, adiponectin, HbA1C, uric acid, total cholesterol, triglycerides, HDL-C and LDL-C Plasma levels of adiponectin in OD [10.60 +/- 3.64microg/mL] and OB [11.21 +/- 3.41microg/mL] were significantly lower than NOND controls [14.73 +/- 4.97microg/mL]. Significant, inverse correlations were observed between adiponectin levels and BMI [r=-0.241, p < 0.05], plasma glucose [r=-0.221, p < 0.05], insulin [r=-0.280, p < 0.05], C-peptide [r=-0.334, P < 0.01], total cholesterol [r=-0.243, p < 0.01,], triglycerides [r=-0.438, p < 0.01], LDL-C [r=-0.214, p < 0.05] and uric acid [r=-0.286, p < 0.05]. In addition, correlated positively with HDL-C[r=0.386, p < 0.01]. In multiple regression analysis, only TG was inversely associated with plasma level of adiponectin in all groups. This study provides the first evidence that adiponectin is reduced in Qatari obese subjects with and without diabetes. The measurement of circulating adiponectin among Qatari obese subjects is suggested to monitor cardiovascular disease [CVD] risks. Whether the plasma adiponectin level could be a suitable biomarker for following the clinical progress of CVD among Qatari obese and diabetic subjects warrants further investigation

Hypokalemia and uncontrolled hypertension

In a 45-year-old female with chronic uncontrolled hypertension complicated by hypokalemia, laboratory and radiological findings were consistent with an aldosterone producing adenoma [APA]. Diagnosis of Conn's syndrome was confirmed by histopathology. The hypokalemia resolved and her hypertension improved after laparoscopic adrenalectomy. Discussion of the case, diagnosis and treatment are presented